Coverart for item
The Resource Psychoneuroimmunology and chronic pain, by Sarah E. Giron

Psychoneuroimmunology and chronic pain, by Sarah E. Giron

Label
Psychoneuroimmunology and chronic pain
Title
Psychoneuroimmunology and chronic pain
Statement of responsibility
by Sarah E. Giron
Creator
Contributor
Author
Subject
Genre
Language
eng
Summary
There is increasing evidence linking chronic pain to altered levels of central nervous system (CNS) inflammation and increased levels of perceived pain, anxiety, depression and sleep disturbance. However the inflammatory molecules responsible for physiologic and psychological components of chronic pain still warrant identification and exploration. Using central inflammation as a paramount factor in the creation and maintenance of chronic pain, this study aimed to investigate and describe the physical and psychological aspects of chronic pain associated with CNS inflammation. Using a cross-sectional correlational design, cerebrospinal fluid (CSF) inflammatory cytokine patterns present in 8 chronic pain participants were compared to inflammatory cytokine patterns present in 30 control CSF samples using multivariate analysis of variance (MANOVA), with analysis of variance (ANOVA) analysis as a follow-up. Levels of depression, anxiety, sleep disturbance and pain were measured in approximately 8 chronic pain patients and correlated to CSF levels of inflammatory cytokines using Pearson’s r, or Spearman’s Rho correlations. Demographic information was also explored for relationships to central inflammation and descriptive statistics were examined for responses. To our knowledge, this is the first study to describe increased CSF levels of Interleukin-8 (IL-8) in a population of majority Failed Back Surgery Syndrome chronic pain patients (F (1, 36) = 14.89, p < 0.001, partial η2 = 0.293). Gender (F (1,6) = 7.782, p = 0.565), socioeconomic status (r = -0.823, p = 0.012) and educational level (r = 0.727, p = 0.041) were also correlated with central levels of inflammation, indicating that central physiologic changes may be related to host sex and psychosocial factors. All participants reported poor sleep quality and took at least one opioid medication, indicating that sleep and opioids may scaffold a portion of the chronic pain paradigm. This study richly describes the dynamic experience of chronic pain through the lens of Psychoneuroimmunology. Incorporating both physiologic and psychological aspects of the disease, this study describes an association between chronic pain, central inflammation, gender, socioeconomic status, opioid medications and poor sleep quality. Thus, the future of pain treatment must consider these aspects when treating patients and look to future studies for possible new treatment options which target these factors
Member of
Cataloging source
CDU
http://library.link/vocab/creatorName
Giron, Sarah E
Degree
(Ph.D.)
Dissertation note
Dissertation
Dissertation year
2015
Granting institution
University of San Diego
Illustrations
illustrations
Index
no index present
LC call number
QP356.47
LC item number
.G57 2015eb
Literary form
non fiction
Nature of contents
  • bibliography
  • theses
http://library.link/vocab/relatedWorkOrContributorName
University of San Diego
Series statement
Dissertation series University of San Diego
Series volume
2015
http://library.link/vocab/subjectName
  • Psychoneuroimmunology
  • Chronic pain
  • Chronic pain
Label
Psychoneuroimmunology and chronic pain, by Sarah E. Giron
Instantiates
Publication
Contributor
Note
Dissertation committee: Joseph F. Burkard, Chair; Jane Georges; Charles A. Griffis -- title page
Bibliography note
Includes bibliographical references
Carrier category
online resource
Carrier category code
cr
Carrier MARC source
rdacarrier
Content category
text
Content type code
txt
Content type MARC source
rdacontent
Control code
956545751
http://bibfra.me/vocab/relation/dissertationadvisor
udGllDO8nw0
Extent
1 online resource (viii, 325 pages)
File format
one file format
Form of item
online
Media category
computer
Media MARC source
rdamedia
Media type code
c
Other physical details
illustrations
Specific material designation
remote
System control number
(OCoLC)956545751
Label
Psychoneuroimmunology and chronic pain, by Sarah E. Giron
Publication
Contributor
Note
Dissertation committee: Joseph F. Burkard, Chair; Jane Georges; Charles A. Griffis -- title page
Bibliography note
Includes bibliographical references
Carrier category
online resource
Carrier category code
cr
Carrier MARC source
rdacarrier
Content category
text
Content type code
txt
Content type MARC source
rdacontent
Control code
956545751
http://bibfra.me/vocab/relation/dissertationadvisor
udGllDO8nw0
Extent
1 online resource (viii, 325 pages)
File format
one file format
Form of item
online
Media category
computer
Media MARC source
rdamedia
Media type code
c
Other physical details
illustrations
Specific material designation
remote
System control number
(OCoLC)956545751

Library Locations

    • Copley LibraryBorrow it
      5998 Alcalá Park, San Diego, CA, 92110-2492, US
      32.771354 -117.193327
Processing Feedback ...